Carnegie Science, Carnegie Institution, Carnegie Institution for Science,
Baltimore, MD— The brain is the body’s mission control center, sending messages to the other organs about how to respond to various external and internal stimuli. Located in the forebrain, the...
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Carnegie Science, Carnegie Institution, Carnegie Institution for Science,
Washington, D.C.--Yixian Zheng has been selected to direct Carnegie’s Department of Embryology in Baltimore, Maryland. She has been Acting Director since February 1st of 2016. Carnegie president...
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Washington, D.C.—BioEYES was accepted to participate in a National Science Foundation (NSF) video competition on May 15-22, 2017. BioEYES supporters are encouraged to go to the competition website at...
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On Tuesday night, George Church told us that a fascination with animatronic Abraham Lincoln at the 1964 World’s Fair partially inspired him to become a scientist. This seems fitting, somehow, since...
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Carnegie Science, Carnegie Institution, Carnegie Institution for Science
Baltimore, MD—Studying how our bodies metabolize lipids such as fatty acids, triglycerides, and cholesterol can teach us about cardiovascular disease, diabetes, and other health problems, as well as...
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People often call dogs “man’s best friend.” But after Elaine Ostrander’s presentation at our Washington, DC, headquarters Thursday, we think that moniker should probably be amended to “geneticist’s...
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Baltimore, MD—A first-of-its-kind study on almost 20,000 K-12 underrepresented public school students shows that Project BioEYES, based at Carnegie’s Department of Embryology, is effective at...
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Carnegie Science, Carnegie Institution, Carnegie Institution for Science
Baltimore, MD— New work led by Carnegie’s Steven Farber, with help from Yixian Zheng’s lab, sheds light on how form follows function for intestinal cells responding to high-fat foods that are rich in...
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Stem cells make headline news as potential treatments for a variety of diseases. But undertstanding the nuts and bolts of how they develop from an undifferentiated cell  that gives rise to cells that are specialized such as organs, or bones, and the nervous system, is not well understood.  The...
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In mammals, most lipids, such as fatty acids and cholesterol, are absorbed into the body via the small intestine. The complexity of the cells and fluids that inhabit this organ make it very difficult to study in a laboratory setting. The goal of the Farber lab is to better understand the cell and...
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The Zheng lab studies cell division including the study of stem cells, genome organization, and lineage specification. They study the mechanism of genome organization in development, homeostasis—metabolic balance-- and aging; and the influence of cell morphogenesis, or cell shape and steructure, ...
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Integrity of hereditary material—the genome —is critical for species survival. Genomes need protection from agents that can cause mutations affecting DNA coding, regulatory functions, and duplication during cell division. DNA sequences called transposons, or jumping genes (discovered by Carnegie’s...
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Junior investigator Zhao Zhang joined Carnegie in November 2014. He studies how elements with the ability to “jump” around the genome, called transposons, are controlled in egg, sperm, and other somatic tissues in order to understand how transposons contribute to genomic instability and to...
Meet this Scientist
Staff associate Christoph Lepper, with colleagues, overturned previous research that identified critical genes for making muscle stem cells. It turns out that the genes that make muscle stem cells in the embryo are surprisingly not needed in adult muscle stem cells to regenerate muscles after...
Meet this Scientist
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Washington, D.C.—BioEYES was accepted to participate in a National Science Foundation (NSF) video competition on May 15-22, 2017. BioEYES supporters are encouraged to go to the competition website at...
Explore this Story
Baltimore, MD—The newest member of the staff at the Carnegie Department of Embryology, Junior Investigator Zhao Zhang, received the prestigious Larry Sandler Memorial Award at the 56th Annual...
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Baltimore, MD—Mammalian females ovulate periodically over their reproductive lifetimes, placing significant demands on their ovaries for egg production. Whether mammals generate new eggs in adulthood...
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Explore Carnegie Science

Carnegie Science, Carnegie Institution, Carnegie Institution for Science,
July 13, 2017

Baltimore, MD— The brain is the body’s mission control center, sending messages to the other organs about how to respond to various external and internal stimuli. Located in the forebrain, the habenular region is one such message-conducting system. Two new papers from Carnegie scientists explain how the habenulae develop and their unsuspected role in recovering from fear.

Found in all vertebrates, the bilaterally paired habenulae regulate the transmission of dopamine and serotonin, two important chemicals related to motor control, mood, and learning.

Previous research has shown that the habenular system is involved in modulating sleep cycles, anxiety, and pain and reward

Carnegie Science, Carnegie Institution, Carnegie Institution for Science,
July 6, 2017

Washington, D.C.--Yixian Zheng has been selected to direct Carnegie’s Department of Embryology in Baltimore, Maryland. She has been Acting Director since February 1st of 2016.

Carnegie president Matthew Scott remarked, “Yixian has been an exceptional leader of the department as Acting Director. We are extremely pleased that she took on this job permanently.  Her fascinating science, independent thinking, vision, extraordinary management skills, and perfect temperament are a tremendous asset to Carnegie Science.”

The Zheng lab has a long-standing interest in cell division and the cytoskeleton—the lattice arrangement of rods and fibers and motors that gives shape to cells and

May 15, 2017

Washington, D.C.—BioEYES was accepted to participate in a National Science Foundation (NSF) video competition on May 15-22, 2017. BioEYES supporters are encouraged to go to the competition website at stemforall2017.videohall.com and share and vote for the BioEYES video! (Note the guidelines for the three ways to vote. Watch the video directly here http://stemforall2017.videohall.com/p/1025)

Project BioEYES, based at Carnegie’s Department of Embryology in Baltimore, MD, (www.bioeyes.org) uses live zebrafish to teach basic scientific principles, animal development, and genetics to underrepresented students, while training teachers in Science, Technology, Engineering and Mathematics

Carnegie Science, Carnegie Institution, Carnegie Institution for Science
May 8, 2017

Baltimore, MD—Studying how our bodies metabolize lipids such as fatty acids, triglycerides, and cholesterol can teach us about cardiovascular disease, diabetes, and other health problems, as well as reveal basic cellular functions. But the process of studying what happens to lipids after being consumed has been both technologically difficult and expensive to accomplish until now.

New work from Carnegie’s Steven Farber and his graduate student Vanessa Quinlivan debuts a method using fluorescent tagging to visualize and help measure lipids in real time as they are metabolized by living fish. Their work is published by the Journal of Lipid Research.

“Lipids play a vital role

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Stem cells make headline news as potential treatments for a variety of diseases. But undertstanding the nuts and bolts of how they develop from an undifferentiated cell  that gives rise to cells that are specialized such as organs, or bones, and the nervous system, is not well understood. 

The Lepper lab studies the mechanics of these processes. overturned previous research that identified critical genes for making muscle stem cells. It turns out that the genes that make muscle stem cells in the embryo are surprisingly not needed in adult muscle stem cells to regenerate muscles after injury. The finding challenges the current course of research into muscular dystrophy, muscle

The Fan laboratory studies the molecular mechanisms that govern mammalian development, using the mouse as a model. They use a combination of biochemical, molecular and genetic approaches to identify and characterize signaling molecules and pathways that control the development and maintenance of the musculoskeletal and hypothalamic systems.

The musculoskeletal system provides the mechanical support for our posture and movement. How it arises during embryogenesis pertains to the basic problem of embryonic induction. How the components of this system are repaired after injury and maintained throughout life is of biological and clinical significance. They study how this system is

The Gall laboratory studies all aspects of the cell nucleus, particularly the structure of chromosomes, the transcription and processing of RNA, and the role of bodies inside the cell nucleus, especially the Cajal body (CB) and the histone locus body (HLB).

Much of the work makes use of the giant oocyte of amphibians and the equally giant nucleus or germinal vesicle (GV) found in it. He is particularly  interested in how the structure of the nucleus is related to the synthesis and processing of RNA—specifically, what changes occur in the chromosomes and other nuclear components when RNA is synthesized, processed, and transported to the cytoplasm.

The Spradling laboratory studies the biology of reproduction. By unknown means eggs reset the normally irreversible processes of differentiation and aging. The fruit fly Drosophila provides a favorable multicellular system for molecular genetic studies. The lab focuses on several aspects of egg development, called oogenesis, which promises to provide insight into the rejuvenation of the nucleus and surrounding cytoplasm. By studying ovarian stem cells, they are learning how cells maintain an undifferentiated state and how cell production is regulated by microenvironments known as niches. They are  also re-investigating the role of steroid and prostaglandin hormones in controlling the

Yixian Zheng’s lab has a long-standing interest in cell division. In recent years, their findings have broadened their research using animal models, to include the study of stem cells, genome organization, and lineage specification—how stem cells differentiate into their final cell forms. They use a wide range of tools, including genetics in different model organisms, cell culture, biochemistry, proteomics, and genomics.

Cell division is essential for all organisms to grow and live. During a specific time in a cell’s cycle the elongated apparatus consisting of string-like micro-tubules called the spindle is assembled to move the chromosomes into two new cells. Another structure

There is a lot of folklore about left-brain, right-brain differences—the right side of the brain is supposed to be the creative side, while the left is the logical half. But it’s much more complicated than that. Marnie Halpern studies how left-right differences arise in the developing brain and discovers the genes that control this asymmetry.

Using the tiny zebrafish, Danio rerio, Halpern explores how regional specializations occur within the neural tube, the embryonic tissue that develops into the brain and spinal cord. The zebrafish is ideal for these studies because its basic body plan is set within 24 hours of fertilization. By day five, young larvae are able to feed and swim

Junior investigator Zhao Zhang joined Carnegie in November 2014. He studies how elements with the ability to “jump” around the genome, called transposons, are controlled in egg, sperm, and other somatic tissues in order to understand how transposons contribute to genomic instability and to mutations that lead to inherited disease and cancer. He particularly focuses on transposon control and its consequences in gonads compared to other tissues and has discovered novel connections to how gene transcripts are processed in the nucleus.To accomplish this work, Zhang frequently develops new tools and techniques, a characteristic of many outstanding Carnegie researchers. He recently received

Allan Spradling is a Howard Hughes Medical Institute Investigator and director of the Department of Embryology. His laboratory studies the biology of reproduction particularly egg cells, which are able to reset the normally irreversible processes of differentiation and aging that govern all somatic cells—those that turn into non-reproductive tissues. Spradling uses the fruit fly Drosophila because the genes and processes studied are likely to be similar to those in other organisms including humans. In the 1980s he and his colleague, Gerald Rubin, showed how jumping genes could be used to identify and manipulate fruit fly genes. Their innovative technique helped establish Drosophila as