GDNF repairs aged muscle stem cells courtesy of Liangji Li.
Washington, DC— An age-related decline in recovery from muscle injury can be traced to a protein that suppresses the special ability of muscle stem cells to build new muscles, according to work...
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This image captures the bright blue light (chemiluminesc ence) emitted by the NanoLuc protein in LipoGlo zebrafish. It is is provided courtesy of James Thierer.
Baltimore, MD—A newly developed technique that shows artery clogging fat-and-protein complexes in live fish gave investigators from Carnegie, Johns Hopkins University, and the Mayo Clinic a...
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One analogy for understanding the mathematical structure of the team's work is to think of it as foam being simplified into a single bubble by progressively merging adjacent bubbles.
Baltimore, MD—How do the communities of microbes living in our gastrointestinal systems affect our health? Carnegie’s Will Ludington was part of a team that helped answer this question....
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Meredith Wilson, a postdoctoral associate in Steve Farber’s lab at the Department of Embryology, has been awarded Carnegie’s thirteenth Postdoctoral Innovation and Excellence Award. These...
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Illustration of a thymus in a human chest courtesy of Navid Marvi.
Washington, DC—Aging-related inflammation can drive the decline of a critical structural protein called lamin-B1, which contributes to diminished immune function in the thymus, according to...
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Steve Farber photo by Navid Marvi, Carnegie Institution for Science
Baltimore, MD—This week Carnegie’s Steve Farber will be recognized by New England Biolabs Inc. with its Passion in Science Award in the category of Mentorship and Advocacy. The company,...
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Michael Diamreyan with Yixian Zheng, Frederick Tan, and Minjie Hu
Baltimore, MD—Michael Diamreyan, a Johns Hopkins University undergraduate biophysics student with a Carnegie connection, has been awarded two prestigious research grants to further his...
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Super-resolution image of fly gut crypts colonized by the native Lactobacillus (red) and Acetobacter (green) bacteria. Fly cell nuclei appear blue. Image is courtesy of Benjamin Obadia.
Baltimore, MD—The interactions that take place between the species of microbes living in the gastrointestinal system often have large and unpredicted effects on health, according to new work...
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The Spradling laboratory studies the biology of reproduction. By unknown means eggs reset the normally irreversible processes of differentiation and aging. The fruit fly Drosophila provides a favorable multicellular system for molecular genetic studies. The lab focuses on several aspects of egg...
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The Fan laboratory studies the molecular mechanisms that govern mammalian development, using the mouse as a model. They use a combination of biochemical, molecular and genetic approaches to identify and characterize signaling molecules and pathways that control the development and maintenance of...
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The Zheng lab studies cell division including the study of stem cells, genome organization, and lineage specification. They study the mechanism of genome organization in development, homeostasis—metabolic balance-- and aging; and the influence of cell morphogenesis, or cell shape and...
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The first step in gene expression is the formation of an RNA copy of its DNA. This step, called transcription, takes place in the cell nucleus. Transcription requires an enzyme called RNA polymerase to catalyze the synthesis of the RNA from the DNA template. This, in addition to other processing...
Meet this Scientist
Allan Spradling is a Howard Hughes Medical Institute Investigator and director of the Department of Embryology. His laboratory studies the biology of reproduction particularly egg cells, which are able to reset the normally irreversible processes of differentiation and aging that govern all somatic...
Meet this Scientist
Brittany Belin joined the Department of Embryology staff in August 2020. Her Ph.D. research involved developing new tools for in vivo imaging of actin in cell nuclei. Actin is a major structural element in eukaryotic cells—cells with a nucleus and organelles —forming contractile...
Meet this Scientist
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Tasuku Honjo, a postdoctoral fellow in the Brown Lab at the Department of Embryology 1971-1973 shares the 2018 Nobel Prize in Physiology or Medicine.  
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AudioBaltimore, MD—In researching neural pathways, it helps to establish an analogous relationship between a region of the human brain and the brains of more-easily studied animal species. New work...
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Baltimore, MD—Director Emeritus Donald Brown, of Carnegie’s Department of Embryology, receives the prestigious 2012 Lasker-Koshland Special Achievement Award in Medical Science “For exceptional...
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Explore Carnegie Science

Experimental zebrafish larvae, courtesy Navid Marvi.
August 7, 2020

Baltimore, MD—New work led by Carnegie’s Meredith Wilson and Steve Farber identifies a potential therapeutic target for clogged arteries and other health risks that stem from an excess of harmful fats in the bloodstream.  Their findings are published by PLOS Genetics. 

“Cardiovascular disease occurs when lipids from the blood plasma are deposited in the walls of blood vessels, ultimately restricting blood flow,” explained Farber, who specializes in elucidating how cells process lipids. “This complex disease affects about a third of the world’s population, so improving our understanding of the mechanisms that regulate the levels of

Xenia in Carnegie's coral facility, courtesy Carnegie Embryology
June 17, 2020

Baltimore, MD— New work from a team of Carnegie cell, genomic, and developmental biologists solves a longstanding marine science mystery that could aid coral conservation. The researchers identified the type of cell that enables a soft coral to recognize and take up the photosynthetic algae with which it maintains a symbiotic relationship, as well as the genes responsible for this transaction.

Their breakthrough research is published in Nature.

Corals are marine invertebrates that build large exoskeletons from which reefs are constructed. But this architecture is only possible because of a mutually beneficial relationship between the coral and various species of

Yixian Zheng
March 11, 2020

Baltimore, MD— Carnegie’s Director of Embryology Yixian Zheng is one of 15 scientists awarded a grant from the Gordon and Betty Moore Foundation to support research on symbiosis in aquatic systems.

For the past two years, Zheng and her colleagues have been working to elucidate the molecular mechanisms of endosymbiosis in the relationships between coral and jellyfish and the photosynthetic algal species that they host. She has been building on Carnegie’s longstanding tradition of model organism development to begin revealing the genetics underlying the uptake and sustenance of symbiotic dinoflagellates by the soft coral species Xenia.

“I have always

Illustration courtesy of Navid Marvi and Andres Aranda-Diaz.
March 5, 2020

Baltimore, MD—Antibiotics can make easy work of infections. But how do they affect the complex ecosystems of friendly bacteria that make up our microbiome?

“When a doctor prescribes antibiotics, it sets up a multi-faceted experiment in your gastrointestinal system,” explains Carnegie’s Will Ludington “What can it teach us about the molecular principles of species interactions in nature?”

New work led by Ludington and Stanford University’s K.C. Huang set out to answer this challenging question and discovered a new form of antibiotic tolerance. Their findings, which have important health implications, are published by eLife.

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Approximately half of the gene sequences of human and mouse genomes comes from so-called mobile elements—genes that jump around the genome. Much of this DNA is no longer capable of moving, but is likely “auditioning”  perhaps as a regulator of gene function or in homologous recombination, which is a type of genetic recombination where the basic structural units of DNA,  nucleotide sequences, are exchanged between two DNA molecules to  repair  breaks in the DNA  strands. Modern mammalian genomes also contain numerous intact movable elements, such as retrotransposon LINE-1, that use RNA intermediates to spread about the genome. 

Given

The Spradling laboratory studies the biology of reproduction. By unknown means eggs reset the normally irreversible processes of differentiation and aging. The fruit fly Drosophila provides a favorable multicellular system for molecular genetic studies. The lab focuses on several aspects of egg development, called oogenesis, which promises to provide insight into the rejuvenation of the nucleus and surrounding cytoplasm. By studying ovarian stem cells, they are learning how cells maintain an undifferentiated state and how cell production is regulated by microenvironments known as niches. They are  also re-investigating the role of steroid and prostaglandin hormones in controlling

The Fan laboratory studies the molecular mechanisms that govern mammalian development, using the mouse as a model. They use a combination of biochemical, molecular and genetic approaches to identify and characterize signaling molecules and pathways that control the development and maintenance of the musculoskeletal and hypothalamic systems.

The musculoskeletal system provides the mechanical support for our posture and movement. How it arises during embryogenesis pertains to the basic problem of embryonic induction. How the components of this system are repaired after injury and maintained throughout life is of biological and clinical significance. They study how this system is

The Marnie Halpern laboratory studies how left-right differences arise in the developing brain and discovers the genes that control this asymmetry. Using the tiny zebrafish, Danio rerio, they explores how regional specializations occur within the neural tube, the embryonic tissue that develops into the brain and spinal cord.

The zebrafish is ideal for these studies because its basic body plan is set within 24 hours of fertilization. By day five, young larvae are able to feed and swim, and within three months they are ready to reproduce. They are also prolific breeders. Most importantly the embryos are transparent, allowing scientists to watch the nervous system develop and to

Steven Farber

In mammals, most lipids, such as fatty acids and cholesterol, are absorbed into the body via the small intestine. The complexity of the cells and fluids that inhabit this organ make it very difficult to study in a laboratory setting. The goal of the Farber lab is to better understand the cell and molecular biology of lipids within digestive organs by exploiting the many unique attributes of the clear zebrafish larva  to visualize lipid uptake and processing in real time.  Given their utmost necessity for proper cellular function, it is not surprising that defects in lipid metabolism underlie a number of human diseases, including obesity, diabetes, and atherosclerosis.

Brittany Belin joined the Department of Embryology staff in August 2020. Her Ph.D. research involved developing new tools for in vivo imaging of actin in cell nuclei. Actin is a major structural element in eukaryotic cells—cells with a nucleus and organelles —forming contractile polymers that drive muscle contraction, the migration of immune cells to  infection sites, and the movement of signals from one part of a cell to another. Using the tools developed in her Ph.D., Belin discovered a new role for actin in aiding the repair of DNA breaks in human cells caused by carcinogens, UV light, and other mutagens.

Belin changed course for her postdoctoral work, in

Allan Spradling is a Howard Hughes Medical Institute Investigator and director of the Department of Embryology. His laboratory studies the biology of reproduction particularly egg cells, which are able to reset the normally irreversible processes of differentiation and aging that govern all somatic cells—those that turn into non-reproductive tissues. Spradling uses the fruit fly Drosophila because the genes and processes studied are likely to be similar to those in other organisms including humans. In the 1980s he and his colleague, Gerald Rubin, showed how jumping genes could be used to identify and manipulate fruit fly genes. Their innovative technique helped establish Drosophila

Frederick Tan holds a unique position at Embryology in this era of high-throughput sequencing where determining DNA and RNA sequences has become one of the most powerful technologies in biology. DNA provides the basic code shared by all our cells to program our development. While there are about 30,000 human genes, 98% of DNA sequences are comprised of repetitive and regulatory sequences within and between genes. Measuring the specific set of DNA sequences that are transcribed into RNA helps reveal what and how our tissues are doing by showing which genes are active.

Modern sequencing platforms, such as the Illumina HiSeq 2000, generate only short, ordered sequences, usually 100