Genetics & Developmental Biology Stories
December 9, 2013
In researching neural pathways, it helps to establish an analogous relationship between a region of the human brain and the brains of more-easily studied animal species. New work...
November 7, 2013
Inside every plant cell, a cytoskeleton provides an interior scaffolding to direct construction of the cell’s walls, and thus the growth of the organism as a whole....
Baltimore, MD--Cells in the body wear down over time and die. In many organs, like the small intestine, adult stem cells play a vital role in maintaining function by replacing old cells with new ones...
AudioBaltimore, MD—Proper tissue function and regeneration is supported by stem cells, which reside in so-called niches. New work from...
Baltimore, MD—Mammalian females ovulate periodically over their reproductive lifetimes, placing significant demands on their ovaries for egg production. Whether mammals generate new eggs in adulthood...
Baltimore, MD— Eggs take a long time to produce in the ovary, and thus are one of a body’s precious resources. It has been theorized that the body has mechanisms to help the ovary ensure that...
Baltimore, MD— The ability of embryonic stem cells to differentiate into different types of cells with different functions is regulated and maintained by a complex series of chemical interactions,...
Washington, D.C.—The Carnegie Institution for Science and the University of Massachusetts Medical School (UMMS) have been granted United States Patent 8,283,329, entitled, “Genetic inhibition of...
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The Marnie Halpern laboratory studies how left-right differences arise in the developing brain and discovers the genes that control this asymmetry. Using the tiny zebrafish, Danio rerio, they explores how regional specializations occur within the neural tube, the embryonic tissue that develops into...
Approximately half of the gene sequences of human and mouse genomes comes from so-called mobile elements—genes that jump around the genome. Much of this DNA is no longer capable of moving, but is likely “auditioning” perhaps as a regulator of gene function or in homologous...
The Fan laboratory studies the molecular mechanisms that govern mammalian development, using the mouse as a model. They use a combination of biochemical, molecular and genetic approaches to identify and characterize signaling molecules and pathways that control the development and maintenance of...
The mouse is a traditional model organism for understanding physiological processes in humans. Chen-Ming Fan uses the mouse to study the underlying mechanisms involved in human development and genetic diseases. He concentrates on identifying and understanding the signals that direct the...
Allan Spradling is a Howard Hughes Medical Institute Investigator and director of the Department of Embryology. His laboratory studies the biology of reproduction particularly egg cells, which are able to reset the normally irreversible processes of differentiation and aging that govern all somatic...
There is a lot of folklore about left-brain, right-brain differences—the right side of the brain is supposed to be the creative side, while the left is the logical half. But it’s much more complicated than that. Marnie Halpern studies how left-right differences arise in the developing...
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Baltimore, MD — In mammals, most lipids (such as fatty acids and cholesterol) are absorbed into the body via the small intestine. The complexity of the cells and fluids that inhabit this organ make...
Body organs such as the intestine and ovaries undergo structural changes in response to dietary nutrients that can have lasting impacts on metabolism, as well as cancer susceptibility, according to...
This week Carnegie’s Steve Farber will be recognized by New England Biolabs Inc. with its Passion in Science Award in the category of Mentorship and Advocacy. Farber co-founded a non-...
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